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IV may be required in some patients

Information for Patients: As with all drugs with beta-blocking activity, certain advice to patients being treated with labetalol HCl is warranted. This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects. Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 8 hours away. Do not take extra medicine to make up the missed dose. What happens if I overdose? Have your blood pressure and pulse heart rate checked regularly while taking this medication. Learn how to check your own blood pressure and pulse at home, and share the results with your doctor. azithromycin canada price azithromycin

How to take trandate

Labetalol has been shown to cross the placental barrier in humans. Only negligible amounts of the drug crossed the blood-brain barrier in animal studies. Labetalol is approximately 50% protein bound. Neither hemodialysis nor peritoneal dialysis removes a significant amount of labetalol HCl from the general circulation less than 1%. EXP on the carton. Tell your doctor if your condition does not improve or if it worsens for example, your remain high or increase. Do not skip doses or stop taking labetalol without first talking to your doctor. Stopping suddenly may make your condition worse. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trandate while you are pregnant. Trandate is found in breast milk. If you are or will be breast-feeding while you use Trandate, check with your doctor. Discuss any possible risks to your baby.

General information about trandate

For the treatment of high blood pressure, it may take several weeks before you get the full benefit of this drug. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Labetalol has been used to treat in women. It is important to control for the health of the mother and unborn baby. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

What are the possible side effects of trandate

This includes any possible side effects not listed in this leaflet. April 9, 2013; March 5, 2013; February 7, 2013; January 25, 2013; December 14, 2012; October 26, 2012; October 3, 2012; September 7, 2012; August 30, 2012; August 7, 2012; July 26, 2012; July 5, 2012; June 22, 2012; May 15, 2012; April 11, 2012; March 22, 2012; February 28, 2012; February 15, 2012; January 30, 2012; January 9, 2012; January 3, 2012; December 15, 2011; November 30, 2011; November 9, 2011; September 30, 2011, University of Utah, Drug Information Service. Perinatal and neonatal distress bradycardia, hypotension, respiratory depression, hypoglycemia, hypothermia has been rarely reported.



HCl and are taken orally

Exacerbation of Ischemic Heart Disease Following Abrupt Withdrawal: Angina pectoris has not been reported upon labetalol HCl discontinuation. However, hypersensitivity to catecholamines has been observed in patients withdrawn from beta-blocker therapy; exacerbation of angina and, in some cases, myocardial infarction have occurred after abrupt discontinuation of such therapy. When discontinuing chronically administered labetalol HCl tablets, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, therapy with labetalol HCl tablets should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Blood Pressure Monitoring: The blood pressure should be monitored during and after completion of the infusion or IV injection. Rapid or excessive falls in either systolic or diastolic blood pressure during IV treatment should be avoided. In patients with excessive systolic hypertension, the decrease in systolic pressure should be used as an indicator of effectiveness in addition to the response of the diastolic pressure. Do not stop taking Trandate suddenly. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems such as a slow heartbeat, second- or third-degree atrioventricular block severe heart failure, breathing problems such as asthma, chronic bronchitis, emphysema. Store at room temperature away from moisture and heat. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Swallow the tablets whole with food. Although beta-adrenergic receptor blockade is useful in the treatment of angina and hypertension, there are also situations in which sympathetic stimulation is vital. For example, in patients with severely damaged hearts, adequate ventricular function may depend on sympathetic drive. Beta-adrenergic blockade may worsen A-V block by preventing the necessary facilitating effects of sympathetic activity on conduction. Beta 2-adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm, and it may also interfere with exogenous bronchodilators in such patients. Chronic Bronchitis and Emphysema: Since Trandate Injection at the usual IV therapeutic doses has not been studied in patients with nonallergic bronchospastic disease, it should not be used in such patients.



What should i avoid while taking trandate

While in the hospital, the dosage of the tablets may be increased at 1 day intervals to achieve the desired blood pressure reduction. What are the side effects of labetalol? Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Exacerbation of angina and, in some cases, myocardial infarction and ventricular dysrhythmias have been reported after abrupt discontinuation of therapy with beta-adrenergic blocking agents in patients with coronary artery disease. Abrupt withdrawal of these agents in patients without coronary artery disease has resulted in transient symptoms, including tremulousness, sweating, palpitation, headache, and malaise. Several mechanisms have been proposed to explain these phenomena, among them increased sensitivity to catecholamines because of increased numbers of beta receptors. Ask your pharmacist about using those products safely. Trandate labetalol is a beta-blocker used to treat . Trandate is available in form. Trandate is to be used only by the patient for whom it is prescribed. Do not share it with other people. HCl caused further dose-related decreases in blood pressure. oxybutynin



What other drugs will affect trandate

NDC 65483-355-02 and 40-mL 200-mg vials, box of one NDC 65483-355-04. Trandate Injection is usually well tolerated. Most adverse effects have been mild and transient and, in controlled trials involving 92 patients, did not require labetalol HCl withdrawal. Symptomatic postural hypotension incidence, 58% is likely to occur if patients are tilted or allowed to assume the upright position within 3 hours of receiving Trandate Injection. Moderate hypotension occurred in 1 of 100 patients while supine. Increased sweating was noted in 4 of 100 patients, and flushing occurred in 1 of 100 patients. The recommended initial dose is 200 mg orally, followed in 6 to 12 hours by an additional dose of 200 or 400 mg orally, depending on the blood pressure response. Beta-adrenergic receptor blocking agents aka beta-blockers in general should not be used in patients with overt congestive heart failure CHF. Sympathetic stimulation may be important in maintaining the hemodynamic function in these patients, thus beta-blockade can worsen the heart failure. As with all drugs with beta-blocking activity, certain advice to patients being treated with labetalol HCl is warranted. While no incident of the abrupt withdrawal phenomenon exacerbation of angina pectoris has been reported with labetalol HCl, dosing with TRANDATE Tablets should not be interrupted or discontinued without a physician's advice. Labetalol HCl Tablets, USP 100 mg are available as round, beige, film-coated tablets debossed with “ WATSON 605” on one side and scored on the other side. They are supplied in bottles of 100, 500, 1000. Clinical Laboratory Tests: Among patients dosed with TRANDATE Tablets, there have been reversible increases of serum transaminases in 4% of patients tested and, more rarely, reversible increases in blood urea. The effects in the nursing infant are unknown. You may have a lot of hair loss 1 to 3 months after severe physical or emotional stress. Your hair usually will grow back within a few months. Trandate Injection is indicated for control of blood pressure in severe hypertension. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Allergic: Fever combined with aching and sore throat, laryngospasm, respiratory distress. Pheochromocytoma: Labetalol HCl has been shown to be effective in lowering blood pressure and relieving symptoms in patients with pheochromocytoma. However, paradoxical hypertensive responses have been reported in a few patients with this tumor; therefore, use caution when administering labetalol HCl to patients with pheochromocytoma. HCl and the logarithm of the plasma concentration. The absolute bioavailability of labetalol is increased when administered with food. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal.



Trandate adult dosage

There is pharmacologic evidence that norepinephrine may be the drug of choice. Lab tests, including liver function, may be performed while you use Trandate tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Since the half-life of this drug is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period; the infusion should be continued until a satisfactory response is obtained and should then be stopped and the oral formulation should be started. Labetalol has been used to treat high blood pressure in pregnant women. It is important to control high blood pressure for the health of the mother and unborn baby. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor the benefits and risks of using this medication during pregnancy. Rarely, babies born to mothers who took labetalol during pregnancy may have symptoms of low blood pressure, slow heartbeat, slow breathing, and low blood sugar such as shaking, unusual sweating for a few days after delivery. Tell the doctor right away if you notice any of these symptoms in your newborn. Trandate may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Pheochromocytoma: Intravenous labetalol HCl has been shown to be effective in lowering blood pressure and relieving symptoms in patients with pheochromocytoma; higher than usual doses may be required. However, paradoxical hypertensive responses have been reported in a few patients with this tumor; therefore, use caution when administering labetalol HCl to patients with pheochromocytoma. Other symptoms of a low blood sugar level, such as dizziness and sweating, are unaffected by this drug. This product may also make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Trandate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. If cardiac failure continues despite adequate digitalization and diuretic, therapy with Trandate Injection should be withdrawn gradually, if possible. Labetalol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. chloramphenicol free shipping



Trandate warnings

If the patient has laboratory evidence of liver injury or jaundice, labetalol should be stopped and not restarted. The metabolism of labetalol is mainly through conjugation to glucuronide metabolites. These metabolites are present in plasma and are excreted in the urine and, via the bile, into the feces. Pharmacokinetics and Metabolism: Labetalol HCl is completely absorbed from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The relative bioavailability of labetalol HCl tablets compared to an oral solution is 100%. The absolute bioavailability fraction of drug reaching systemic circulation of labetalol when compared to an intravenous infusion is 25%; this is due to extensive “first-pass” metabolism. Labetalol HCl combines both selective, competitive, alpha1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. Tablets Product Information for details. Certain of the side effects increased with increasing oral dose, as shown in the following table that depicts the entire US therapeutic trials data base for adverse reactions that are clearly or possibly dose related. Due to the alpha 1-receptor blocking activity of labetalol HCl, blood pressure is lowered more in the standing than in the supine position, and symptoms of postural hypotension 2% including rare instances of syncope, can occur. Following oral administration, when postural hypotension has occurred, it has been transient and is uncommon when the recommended starting dose and titration increments are closely followed see . Symptomatic postural hypotension is most likely to occur 2 to 4 hours after a dose, especially following the use of large initial doses or upon large changes in dose. Diabetes patients - Trandate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.



It also widens the arteries in the body

Diabetes patients - Trandate tablets may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to the side effects of this drug, including dizziness and lightheadedness. Decreased sexual ability has been reported rarely. If any of these effects persist or worsen, tell your doctor or promptly. Ask your health care provider any questions you may have about how to use Trandate. NDC 65483-393-10 and 500 NDC 65483-393-50 and unit dose packs of 100 tablets NDC 65483-393-33. HCl and are taken orally. Because of the low levels of this drug in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in full-term breastfed infants. No special precautions are required in most infants; however, other agents may be preferred while nursing a preterm infant. The recommended initial dosage of Trandate is 100 mg twice daily. The usual maintenance dose range is 200 - 400 mg twice daily. Trandate may interact with treatments, clonidine, guanabenz, MAO inhibitors, medication, heart medication, medicine for or other breathing disorders, cold medicines, stimulant medicines, or diet pills. Tell your doctor all medications you use. Trandate may be used to treat high blood pressure in pregnant women. It is important to control high blood pressure for the health of the mother and fetus. Several deaths have occurred when TRANDATE labetalol HCI Injection was used during surgery including when used in cases to control bleeding. Keep out of the reach and sight of children. Patients should always be kept in a supine position during the period of IV drug administration. A substantial fall in blood pressure on standing should be expected in these patients. The patient's ability to tolerate an upright position should be established before permitting any ambulation, such as using toilet facilities. HCl and a molecular weight of 364. Labetalol HCl combines both selective, competitive, alpha 1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. generic asacol buy store



What conditions does trandate treat

Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect. If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur. Beta-blockers, even those with apparent cardioselectivity, should not be used in patients with a history of obstructive airway disease, including asthma. Hair follicles are the openings that hair grows from. R' stereoisomer, makes up 25% of racemic labetalol. Body as a Whole: Fever.



Reviews for trandate

Your diabetes medication or diet may need to be adjusted. How should I take Trandate labetalol? Hair may grow back on its own. In some cases, treatment may help. Labor and Delivery: Labetalol HCl given to pregnant women with hypertension did not appear to affect the usual course of labor and delivery. Use Trandate tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, lightheadedness, or fainting. The relative bioavailability of labetalol HCl tablets compared to an oral solution is 100%. The absolute bioavailability fraction of drug reaching systemic circulation of labetalol when compared to an IV infusion is 25%; this is due to extensive "first-pass" metabolism. Labetalol belongs to a family of medicines known as betablockers. Trandate tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with labetalol HCl. Have your and checked regularly while taking this medication. Learn how to check your own pressure and pulse at home, and share the results with your doctor. bonviva



Not all pack sizes may be marketed

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Make sure laboratory personnel and all your doctors know you use this drug. Dizziness; indigestion; lightheadedness; nausea; stuffy nose; temporary tingling of the scalp; unusual tiredness. The peak effects of single oral doses of labetalol HCl occur within 2 to 4 hours. The duration of effect depends upon dose, lasting at least 8 hours following single oral doses of 100 mg and more than 12 hours following single oral doses of 300 mg. The maximum, steady-state blood pressure response upon oral, twice-a-day dosing occurs within 24 to 72 hours. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Neither hemodialysis nor peritoneal dialysis removes a significant amount of labetalol HCl from the general circulation less than 1%. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Compatibility With Commonly Used Intravenous Fluids: Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit. Blood pressure should be monitored during and after completion of the infusion or IV injections. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue therapy with labetalol HCl tablets abruptly in patients being treated for hypertension. Alternatively, add 40 mL of Trandate Injection to 250 mL of a commonly used IV fluid. Keep this leaflet. You may need to read it again. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.



Trandate dosing information

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Labetalol can pass into breast milk in small amounts. Tell your doctor if you are breast-feeding. Trandate tablets may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Trandate tablets with caution. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Trandate tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. Major Surgery: Do not routinely withdraw chronic beta blocker therapy prior to surgery. Pharmacodynamics: The capacity of labetalol HCl to block alpha receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold water “cold-pressor test”. Labetalol is only part of a complete program of treatment for hypertension that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. What happens if I miss a dose? If you have any questions about Trandate tablets, please talk with your doctor, pharmacist, or other health care provider. The antihypertensive effect of labetalol has a linear correlation with the logarithm of labetalol plasma concentration, and there is also a linear correlation between the reduction in exercise-induced tachycardia occurring at 2 hours after oral administration of labetalol HCl and the logarithm of the plasma concentration. Diabetes patients - Trandate tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. The plasma half-life of labetalol following oral administration is about 6 to 8 hours. Steady-state plasma levels of labetalol during repetitive dosing are reached by about the third day of dosing. In patients with decreased hepatic or renal function, the elimination half-life of labetalol is not altered; however, the relative bioavailability in hepatically impaired patients is increased due to decreased “first-pass” metabolism. cheap uroxatral websites



Important information

Use: For control of blood pressure in severe hypertension What other drugs will affect labetalol? It has two asymmetric centers and therefore exists as a molecular complex of two diastereoisomeric pairs. If angina markedly worsens or acute coronary insufficiency develops, therapy with Trandate Tablets should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician's advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue therapy with Trandate Tablets abruptly in patients being treated for hypertension. Since some elderly patients eliminate labetalol more slowly, however, adequate control of blood pressure may be achieved at a lower maintenance dosage compared to the general population. Changes in hormone levels. Labetalol hydrochloride - Drug Summary - PDR. It is not known whether labetalol will harm an unborn baby. Labetalol may cause heart or lung problems in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while taking labetalol. Elderly Patients: Some pharmacokinetic studies indicate that the elimination of labetalol is reduced in elderly patients. Impaired Hepatic Function: Trandate Tablets should be used with caution in patients with impaired hepatic function since metabolism of the drug may be diminished.



Highlights for trandate

Some medical conditions may interact with Trandate tablets. Injury to the scalp, including scarring. Information for Patients: The following information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects. During and immediately following for up to 3 hours Trandate Injection, the patient should remain supine. Subsequently, the patient should be advised on how to proceed gradually to become ambulatory and should be observed at the time of first ambulation. Hepatic Injury: Severe hepatocellular injury, confirmed by rechallenge in at least one case, occurs rarely with labetalol therapy. The hepatic injury is usually reversible, but hepatic necrosis and death have been reported. Injury has occurred after both short- and long-term treatment and may be slowly progressive despite minimal symptomatology. Similar hepatic events have been reported with a related research compound, dilevalol HCl, including two deaths. Dilevalol HCl is one of the four isomers of labetalol HCl. Thus, for patients taking labetalol, periodic determination of suitable hepatic laboratory tests would be appropriate. Clinical Laboratory Tests: There have been reversible increases of serum transaminases in 4% of patients treated with labetalol HCl and tested and, more rarely, reversible increases in blood urea. This medication passes into milk, and the effect on a nursing is unknown. Consult your doctor before -feeding. This drug may rarely cause serious rarely fatal liver disease. Central and Peripheral Nervous Systems: Paresthesia, most frequently described as scalp tingling. In most cases, it was mild and transient and usually occurred at the beginning of treatment. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. This may not be a complete list of all interactions that may occur. Ask your health care provider if Trandate tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How should I take labetalol? This is especially important with labile diabetics. Beta-blockade also reduces the release of insulin in response to hyperglycemia; it may therefore be necessary to adjust the dose of antidiabetic drugs. Use Trandate as directed by your doctor. Check the label on the medicine for exact dosing instructions. ablon.info glucophage



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Do I need a prescription for labetalol?


Labetalol may be increased

Urinary System: Difficulty in micturition, including acute urinary bladder retention. Scalp tingling may occur as your body adjusts to Trandate. Laboratory Test Interactions: The presence of labetalol metabolites in the urine may result in falsely elevated levels of urinary catecholamines, metanephrine, normetanephrine, and vanillylmandelic acid when measured by fluorimetric or photometric methods. lisinopril rx only lisinopril

Trandate dosage

Trandate Injection was NOT compatible with 5% sodium bicarbonate injection, USP. Care should be taken when administering alkaline drugs, including furosemide, in combination with labetalol. Compatibility should be assured prior to administering these drugs together. Labetalol. Alcohol can make these side effects worse. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Use of trandate

Use in children: Labetalol should not be given to children. Do not take more Trandate than you should. Store Trandate tablets between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trandate tablets out of the reach of children and away from pets. Laboratory Tests: As with any new drug given over prolonged periods, laboratory parameters should be observed over regular intervals. In patients with concomitant illnesses, such as impaired renal function, appropriate tests should be done to monitor these conditions.

Before taking trandate

The metabolism of labetalol is mainly through conjugation to glucuronide metabolites. These metabolites are present in plasma and are excreted in the urine and, via the bile, into the feces. Approximately 55% to 60% of a dose appears in the urine as conjugates or unchanged labetalol within the first 24 hours of dosing. This can lead to heart attacks, kidney failure, stroke or blindness. Cimetidine has been shown to increase the bioavailability of labetalol HCl administered orally. Since this could be explained either by enhanced absorption or by an alteration of hepatic metabolism of labetalol HCl, special care should be used in establishing the dose required for blood pressure control in such patients.

Most adverse effects are mild and transient and occur early in the course of treatment. In controlled clinical trials of 3 to 4 months' duration, discontinuation of Trandate Tablets due to one or more adverse effects was required in 7% of all patients. In these same trials, other agents with solely beta-blocking activity used in the control groups led to discontinuation in 8% to 10% of patients, and a centrally acting alpha-agonist led to discontinuation in 30% of patients. Following Coronary Artery Bypass Surgery: In one uncontrolled study, patients with low cardiac indices and elevated systemic vascular resistance following intravenous labetalol HCl experienced significant declines in cardiac output with little change in systemic vascular resistance. One of these patients developed hypotension following labetalol treatment. Therefore, use of labetalol HCl should be avoided in such patients.

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